P-Selectin, also known as CD62P, GMP-140, PADGEM, and LECAM-3, is a transmembrane adhesion protein that is upregulated on activated platelets and vascular endothelial cells. It binds to hematopoietic cell PSGL-1/CD162 with highly clustered O-linked sialyl Lewis-x (sLex ) tetrasaccharides and sulfated tyrosine, as well as to heparin sulfate,

P-selectin P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. P-selectin functions as a cell adhesion molecule ( CAM)

Not for use in diagnostic procedures. Catalog Number BBE6 Catalog Number SBBE6 Catalog Number PBBE6 For the quantitative determination of human P-Selectin (P-Selectin) in cell culture supernates, serum, and plasma. Sidofältlista: ordna och bläddra begrepp efter kriterier. Lista begrepp alfabetiskt; Alfabetisk; Lista begrepp enligt hierarkin; Hierarki An adhesion receptor molecule for white blood cells that functions during inflammation and tissue repair. Binding with P-selectin glycoprotein ligand 1, it controls the flow of white blood cells and their adhesion to blood vessel walls.

P selectin

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P-Selectin, also known as CD62P, GMP-140, PADGEM, and LECAM-3, is a transmembrane adhesion protein that is upregulated on activated platelets and vascular endothelial cells. It binds to hematopoietic cell PSGL-1/CD162 with highly clustered O-linked sialyl Lewis-x (sLex ) tetrasaccharides and sulfated tyrosine, as well as to heparin sulfate

Diseases associated with SELP include Intermittent Claudication and Arteriosclerosis Obliterans.Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+.Gene Ontology (GO) annotations related to this gene include carbohydrate binding and calcium-dependent protein binding. 2019-12-01 Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

D-dimer, P-selectin, and microparticles: novel markers to predict deep venous thrombosis. A pilot study. Rectenwald JE(1), Myers DD Jr, Hawley AE, Longo C, Henke PK, Guire KE, Schmaier AH, Wakefield TW. Author information: (1)Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, Michigan, USA. jrectenw@umich.edu

3.1 Role in leukocyte Mar 15, 1998 Basically, ligands for L-selectin are found on endothelial cells while ligands for E- and P-selectins are found on leukocytes.

After platelet activation, P-selectin is Abstract. P-selectin glycoprotein ligand 1 (PSGL-1, CD162) and integrin αMβ2 ( Mac-1, CD11bCD18) are leukocyte P-selectin is a transmembrane protein present in the α granules of platelets and the Weibel-Palade bodies of endothelial cells. Following activation, Mayadas et.al confirmed that the combination of P-selectin and its ligand PSGL-1 mediates the adhesion of platelets to vascular endothelial cells and promotes P-Selectin Antibody (AK4) is a monoclonal anti-CD62 antibody that detects human P-Selectin by WB, IP, IF and FCM. Cited in 9 publications. Nov 16, 2017 P-selectin (CD62), a member of the selectin family, is confined to the α-granules of platelets and Weibel-Palade bodies of endothelial cells. P-selectin belongs to the family of selectin adhesion molecules, and is expressed by platelets and endothelial cells on stimulation.
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In this study, a novel P-selectin-targeted, NIR fluorescent dye (Cy 5.5)-labeled dual-modal nanoprobe based on diethylenetriaminepentaacetic chelates (Gd-DTPA-Cy5.5-PsLmAb) was constructed for the bimodal imaging of SAP at the early stage.

Then, the effect of P-selectin on severe acute lung injury induced by Klebsiella pneumoniae in immunocompromised mice was evaluated in subsequent experiments. selectin: ( sĕ-lek'tin ), A cell surface molecule involved in immune adhesion and cell trafficking. [L.
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This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor Clq.

P-selectin glycoprotein ligand 1 and beta Kinetics of platelet P-selectin mobilization: Concurrent surface expression and release induced by thrombin or PMA, and inhibition by the NO Donor SNAP av S Santén · 2009 · Citerat av 14 — Additionally, the role of p38 MAPK in mast cell-generated tumor necrosis factor-α (TNF-α) as well as neutrophil adhesion and P-selectin expression were Artikelnummer: 636393. Produktnamn: Ms X Hu P Selectin. REACH- registreringsnummer: Denna produkt är en blandning.

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P-selectin is a transmembrane protein present in the α granules of platelets and the Weibel-Palade bodies of endothelial cells. Following activation,

Besöksförbud och begränsningar för medföljare 01 mars 2021, 18:19. För att minska smittspridning är det besöksförbud (utom för vårdnadshavare). P-Selectin is a calcium-dependent receptor that funtions as a cell adhesion molecule on the surfaces of activated endothelial cells. It binds to carbohydrates on neutrophils and monocytes. It is the primary ligand for the P-Selectin glycoprotein ligand-1 and is important in the initial recruitment of leukocytes and platelets during inflammation and injury. Recombinant Human P-Selectin Protein (Met1-Ala771) 13025-H02H with a fusion hFc Tag, is expressed in HEK293 Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human P-Selectin protein for relevant bioassay and related research.